The 12-year TAILORx study, co-authored by a VCU Massey Cancer Center physician-researcher, shows chemotherapy does not increase disease-free survival rates for women with early stage breast cancer and an intermediate risk of recurrence.
Seventy percent of women with the most common type of newly diagnosed breast cancer can now be identified and safely skip chemotherapy, according to the results of a landmark 12-year clinical research study.
Data from the Trial Assigning Individualized Options for Treatment show that chemotherapy does not increase disease-free survival rates for women with early stage breast cancer and an intermediate risk of recurrence determined by the Oncotype DX Recurrence Score test. The study was designed to more precisely determine the effect of chemotherapy, if any, for women with hormone receptor (HR)-positive, HER2-negative, axillary lymph node-negative breast cancer.
The grant will fund a clinical trial with 102 heart-disease patients. Researchers will investigate if reducing inflammation in the heart muscle can improve the patients’ health and reduce the need for hospitalization. Researchers expect to begin enrolling patients later this year.
It is the fourth NIH grant for the research team that is co-led by Benjamin Van Tassell, Pharm.D., vice chair for clinical research and associate professor in the VCU School of Pharmacy Department of Pharmacotherapy and Outcomes Science, and Antonio Abbate, M.D., Ph.D., vice chair of the Division of Cardiology in the VCU School of Medicine. The current study will build on encouraging results from a smaller 2016 study also funded by the NIH.
A rendering of protons, neutrons and electrons in an atom.
Virginia Commonwealth University researchers have discovered a novel strategy for creating superatoms — combinations of atoms that can mimic the properties of more than one group of elements of the periodic table. These superatoms could be used to create new materials, including more efficient batteries and better semiconductors; a core component of microchips, transistors and most computerized devices.
Batteries and semiconductors rely on the movement of charges from one group of atoms to another. During this process, electrons are transferred from donor atoms to acceptor atoms. Forming superatoms that can supply or accept multiple electrons while maintaining structural stability is a key requirement for creating better batteries or semiconductors, said Shiv Khanna, Ph.D., Commonwealth Professor and chair of the Department of Physics in the College of Humanities and Sciences. The ability of superatoms to effectively move charges while staying intact is attributed to how they mimic the properties of multiple groups of elements.
“We have devised a new approach in which one can synthesize such metal-based superatoms,” Khanna said.
Unlike traditional forensic testing methods, Christopher Ehrhardt’s procedure can be used to identify different cell types in a sample without damaging the sample.
A Virginia Commonwealth University researcher has developed a procedure for identifying the source of cells present in a forensic biological sample that could change how cell types are identified in samples across numerous industries.
Many traditional techniques for distinguishing between saliva, blood, skin or vaginal tissue in an evidence sample are based on microchemical reactions that can be prone to false-positive or false-negative results, according to the researcher, Christopher Ehrhardt, Ph.D., an associate professor in the Department of Forensic Science in the College of Humanities and Sciences. Additionally, they may be difficult to use on aged or heavily degraded samples.
“The information is often limited,” Ehrhardt said. “And when using conventional methods, you have to be prepared to consume part of the sample in most cases, which decreases the value of it.”
The partnership with Toadfish Outfitters will allow VCU to plant more than 2 million oysters in the Chesapeake Bay watershed.
Virginia Commonwealth University’sVirginia Oyster Shell Recycling Program has partnered with Toadfish Outfitters of Charleston, South Carolina, to advance its efforts to replenish oyster populations in the Chesapeake Bay watershed. Toadfish Outfitters, a manufacturer of coastal lifestyle products, has designated the VOSRP as the sole recipient of proceeds from the sale of Toadfish products in Virginia. VOSRP will use the funding initially to acquire 20 million oyster larvae that will be planted on recycled oyster shell placed in Chesapeake Bay waterways. This will allow VCU to plant more than 2 million oysters in the watershed, and coincides with Chesapeake Bay Awareness Week.
“Oysters are the ultimate friend of the coast as they help to keep our waters clean,” said Casey Davidson, founder of Toadfish Outfitters. “Since day one, we’ve promised to give back a portion of every product sold toward oyster habitat restoration, so working with VCU was a natural fit.”
VOSRP, part of VCU’s Rice Rivers Center, is a collaborative, community-based oyster restoration program that works closely with the Virginia seafood industry. The VOSRP currently collects recycled oyster shells from more than 50 restaurants and 30 public drop-off locations statewide to use in the creation of sanctuary oyster reefs. The shells are seeded with juvenile oysters before they are planted. These efforts are direly needed because the Virginia oyster population is currently estimated to be at two percent of peak numbers.
“We are excited about the new partnership between Toadfish Outfitters and the Virginia Oyster Shell Recycling Program to help bring the Virginia oyster back to Chesapeake Bay,” said Greg Garman, Ph.D., director of VCU Rice Rivers Center. “The work of Toadfish has supported oyster restoration in other states and this contribution will advance our waterway conservation efforts.”
Wei Cheng’s system allows a group of devices to know where they are in relation to one another, and could have hundreds of practical applications, from finding a friend at a concert to locating a Lyft driver at the airport.
A Virginia Commonwealth University computer science professor has developed a system that could change how we find friends in crowded places, Uber drivers in busy cities, and even family spread across a cruise ship.
Unlike GPS, which provides location data based on latitude and longitude, this new system — invented by Wei Cheng, Ph.D., assistant professor in the Department of Computer Science in the College of Engineering — tells users where they are compared to others.
The system allows a group of devices to know where they are in relation to one another, what direction each device is traveling, and how fast each is moving.
“Think of this technology like a swarm of bees,” Cheng said. “The bees all know where the other bees are, and where they’re going.”
The award from the Health Resources and Services Administration in the U.S. Department of Health and Human Services was granted to Tamara Zurakowski, Ph.D., clinical associate professor and director of undergraduate programs in the VCU School of Nursing.
Two VCU faculty are developing a device meant to restore the sense of smell.
Scott Moorehead was thrown into a deep depression when he lost his sense of smell five years ago due to a traumatic brain injury. Moorehead fell in the driveway of his Marion, Indiana, home while teaching his then 6-year-old son, Mason, how to skateboard.
Moorehead suffered a major concussion and internal bleeding, but the long-lasting consequence was severing the connection of the olfactory nerves in his nose to his brain, which resulted in total smell loss, or anosmia.
It is an “invisible injury,” Moorehead said. The sense’s tie to memory and enjoyment made the loss debilitating.
“Until you can’t smell at all you have no idea how emotional the experience can be,” he said. “You start to think about these really awful things, like, someday my daughter is going to get married and I’m going to walk her down the aisle and I’m going to give her a big hug, and I’m going to have no idea what she smelled like.”
VCU Engineering alumnus Shawn Joshi in front of Oxford University’s Radcliffe Camera.
When Shawn Joshi (B.S.’12/H&S; B.S.’12/En) was 14, his brother suffered a severe traumatic brain injury. Joshi was able to find technological solutions for the family’s day-to-day life, and has carried that idea with him to this day.
“While I never saw medical science perform any miracles for his condition, I would say there have been remarkable technologies that have made both his life and our family’s lives easier,” he said. “He has a standing wheelchair that can relieve tension and pressure as it stands and supports him. We have put Alexa in our house and have controlled lights and cameras. And while we can easily Google anything that comes to our mind, he too can ask Alexa for answers and play music any time he wants.”
Bringing independence to people with impairments has been important to Joshi ever since.
“I am always trying to use technology to make life easier for any population that may have a harder time than others,” said Joshi, who graduated from Virginia Commonwealth University in 2012 with dual degrees in physics and biomedical engineering.
At VCU, Joshi worked with Paul Wetzel, Ph.D., associate professor of biomedical engineering in the VCU College of Engineering, to design glasses that could control a computer mouse via eye blinks and head movements. The device could bring independence to people with paraplegia or other disabilities.
Virginia Commonwealth University has been awarded $21.5 million in funding from the National Institutes of Health to promote and expand research and improve access for Virginians to cutting-edge treatments for diseases, including cardiac disease, pulmonary disease and addiction. This is the largest NIH grant ever awarded to VCU.
“As a governor and physician, nothing is more important to me than the heath of Virginians — the Wright Center’s historic grant is a huge boost to the commonwealth’s ability to bring innovations in clinical research that will result in better treatments and new cures,” Northam said. “This funding will support collaboration across the state and speed translation of research to patient care, and I look forward watching VCU solidify Virginia’s place as a research leader.”
Members of Virginia’s congressional delegation, which played an essential role in supporting the grant, celebrated the award Monday.