Three new genetic markers associated with risk for depression

After becoming the first to definitively discover genetic markers for major depression, researchers at Virginia Commonwealth University and collaborators have found more genetic clues to the disease.

study published in the American Journal of Psychiatry details the discovery of three additional genetic risk markers for depression, which builds on the groundbreaking discovery of two genetic risk factors in 2015. Lead authors include Roseann Peterson, Ph.D. (Ph.D.’12/M), an assistant professor of psychiatry at the VCU Virginia Institute for Psychiatric and Behavioral Genetics, and Na Cai of the European Bioinformatics Institute and the Wellcome Sanger Institute in the United Kingdom.

Both sets of findings were the result of an international collaboration among researchers from the Virginia Institute for Psychiatric and Behavioral Genetics, the University of Oxford and throughout China to shed light on genetic causes of the disease. Principal investigators Kenneth Kendler at VCU and Jonathan Flint at the University of California, Los Angeles led this large-scale collaborative effort, which resulted in a study of more than 10,000 Han Chinese women from 50 hospitals across China.

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